- Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma.
H. Friedman, M. Prados, P. Wen, T. Mikkelsen, D. Schiff, L. Abrey, W. Yung, N. Paleologos, M. Nicholas, R. Jensen, J. Vredenburgh, Jane E. Huang, M. Zheng, T. Cloughesy
20092,472 件引用Semantic Scholar
- Three-dimensional optical holography using a plasmonic metasurface
Lingling Huang, Xianzhong Chen, H. Mühlenbernd, Hao Zhang, Shumei Chen, B. Bai, Qiaofeng Tan, Guofan Jin, K. Cheah, C. Qiu, Jensen Li, T. Zentgraf, Shuang Zhang
20131,373 件引用Semantic Scholar
Benefitting from the flexibility in engineering their optical response, metamaterials have been used to achieve control over the propagation of light to an unprecedented level, leading to highly unconventional and versatile optical functionalities compared with their natural counterparts. Recently, the emerging field of metasurfaces, which consist of a monolayer of photonic artificial atoms, has offered attractive functionalities for shaping wave fronts of light by introducing an abrupt interfacial phase discontinuity. Here we realize three-dimensional holography by using metasurfaces made of subwavelength metallic nanorods with spatially varying orientations. The phase discontinuity takes place when the helicity of incident circularly polarized light is reversed. As the phase can be continuously controlled in each subwavelength unit cell by the rod orientation, metasurfaces represent a new route towards high-resolution on-axis three-dimensional holograms with a wide field of view. In addition, the undesired effect of multiple diffraction orders usually accompanying holography is eliminated. Holographic techniques allow for the construction of 3D images by controlling the wave front of light beams. Huang et al.develop ultrathin plasmonic metasurfaces to provide 3D optical holographic image reconstruction in the visible and near-infrared regions for circularly polarized light.
- Development of human protein reference database as an initial platform for approaching systems biology in humans.
Suraj Peri, Suraj Peri, J. Navarro, J. Navarro, Ramars Amanchy, Troels Kristiansen, Troels Kristiansen, Chandra Kiran Jonnalagadda, V. Surendranath, Vidya Niranjan, B. Muthusamy, T. K. Gandhi, M. Grønborg, M. Grønborg, N. Ibarrola, Nandan P. Deshpande, K. Shanker, H. Shivashankar, B. Rashmi, M. Ramya, Zhixing Zhao, K. N. Chandrika, N. Padma, H. C. Harsha, A. J. Yatish, M. Kavitha, M. Menezes, D. R. Choudhury, Shubha Suresh, Neelanjana Ghosh, R. Saravana, Sreenath Chandran, S. Krishna, Mary Joy, S. Anand, V. Madavan, A. Joseph, G. W. Wong, W. Schiemann, S. Constantinescu, L. Huang, R. Khosravi‐Far, H. Steen, M. Tewari, S. Ghaffari, G. Blobe, C. Dang, Joe G. N. Garcia, J. Pevsner, O. Jensen, P. Roepstorff, K. Deshpande, A. Chinnaiyan, A. Hamosh, A. Chakravarti, Akhilesh Pandey
20031,149 件引用Semantic Scholar
- Plant-derived exosomal microRNAs shape the gut microbiota
Y. Teng, Yi Ren, Mohammed Sayed, Xin Hu, Chao Lei, Anil Kumar, E. Hutchins, J. Mu, Zhong-bin Deng, Chao Luo, Kumaran Sundaram, M. Sriwastva, Lifeng Zhang, Michael Hsieh, R. Reiman, B. Haribabu, Jun Yan, V. Jala, Donald M Miller, Kendall Van Keuren-Jensen, M. Merchant, C. McClain, J. Park, N. Egilmez, Huang‐Ge Zhang
2018896 件引用Semantic Scholar
Summary The gut microbiota can be altered by dietary interventions to prevent and treat various diseases. However, the mechanisms by which food products modulate commensals remain largely unknown. We demonstrate that plant-derived exosomes-like nanoparticles (ELNs) are taken up by the gut microbiota and contain RNAs that alter microbiome composition and host physiology. Ginger ELNs (GELNs) are preferentially taken up by Lactobacillaceae in a GELN lipid-dependent manner and contain microRNAs that target various genes in Lactobacillus rhamnosus (LGG). Among these, GELN mdo-miR7267-3p-mediated targeting of the LGG monooxygenase ycnE yields increased indole-3-carboxaldehyde (I3A). GELN RNAs or I3A, a ligand for aryl hydrocarbon receptor (AHR), are sufficient to induce production of IL-22, which is linked to barrier function improvement. These functions of GELN RNAs can ameliorate mouse colitis via IL-22-dependent mechanisms. These findings reveal how plant products and their effects on the microbiome may be used to target specific host processes to alleviate disease.
- Resequencing 50 accessions of cultivated and wild rice yields markers for identifying agronomically important genes
Xun Xu, Xin Liu, S. Ge, J. Jensen, F. Hu, Xin Li, Yang Dong, R. Gutenkunst, L. Fang, Lei Huang, Jingxiang Li, Weiming He, Guojie Zhang, Xiaoming Zheng, Fumin Zhang, Yingrui Li, Chang Yu, K. Kristiansen, Xiuqing Zhang, Jian Wang, Mark H. Wright, S. McCouch, R. Nielsen, Jun Wang, Wen Wang
2011801 件引用Semantic Scholar